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| Opponent | Record |
|---|---|
| Overall | 0-1 |
| Top 25 | 0-0 |
| 26-50 | 0-0 |
| 51-100 | 0-0 |
| 101-200 | 0-1 |
| 200+ | 0-0 |
| Defiance has not been ranked this season on NCAAGameSim.com |
| Date/Time | Matchup/Odds | Prediction | Actual | Result |
|---|---|---|---|---|
| 11/15/2025 3 PM | Defiance @ Oakland  | Oakland wins 113-47 | ||
| 12/22/2025 1 PM | Defiance @ Western Michigan  | |
